The mechanism of action of ciclopirox has been investigated using various in vitro and in vivo infection models. One in vitro study suggested that ciclopirox acts by chelation of polyvalent cations (Fe+3 or Al+3) resulting in the inhibition of the metal-dependent enzymes that are responsible for the degradation of peroxides within the fungal cell. The clinical significance of this observation is not known.
Penlac (Ciclopirox) comes as a solution to apply to nails and the
skin immediately surrounding and under the nails. It is usually
applied once a day. To help you remember to use Penlac (Ciclopirox),
apply it around the same time every day, usually at bedtime. Follow
the directions on your prescription label carefully, and ask your
doctor or pharmacist to explain any part you do not understand.
Use Penlac (Ciclopirox) exactly as directed.
Penlac (Ciclopirox) topical solution may cause side effects. Tell
your doctor if the following symptom is severe or does not go away:
redness at the place where you applied Penlac (Ciclopirox)
Some side effects can be serious. The following symptoms are uncommon,
but if you experience any of them, call your doctor immediately:
irritation, itching, burning, blistering, swelling, or oozing at
the place where you applied Penlac (Ciclopirox)
pain at the affected nail(s) or surrounding area
discoloration or change in shape of nail(s)
ingrown nail(s)